Minister MacCharles slated to attend TICO AGM June 20

first_img<< Previous PostNext Post >> Travelweek Group Minister MacCharles slated to attend TICO AGM June 20 Posted by Sharecenter_img Tuesday, June 13, 2017 TORONTO — Ontario’s Minister of Government and Consumer Services Tracy MacCharles will be on hand to address stakeholders at TICO’s Annual General Meeting on June 20.The AGM starts at 1:30 p.m. at the Mississauga Living Arts Centre at 4141 Living Arts Drive.“With the Ontario Government’s comprehensive review of the Travel Industry Act and Regulation underway, these are both exciting and challenging times for the travel industry and TICO,” said TICO CEO and Registrar, Richard Smart.“We are very honored to welcome Minister MacCharles to TICO’s AGM and look forward to her providing her remarks on Ontario’s consumer protection initiatives and future government priorities.”Smart said he encourages Ontario travel industry stakeholders including travel agents and tour operators “to mark their calendars” and attend TICO’s AGM.A long-awaited review of the Ontario’s Travel Industry Act was finally given the green light by the provincial government in 2016. The goal is to update and modernize the consumer protection legislation, strengthen consumer protection and reduce burden on business. “[The] industry has been asking for a review for some time and TICO is looking forward to working with the Ministry and engaging stakeholders in ensuring a strong consumer protection framework for the future,” said TICO at last year’s AGM. Tags: TICOlast_img read more

The 5 Takeaways from the Coyotes introduction of

first_img The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo Unlike the majority of the season, this time the Cardinals didn’t respond well. Jeremy Lane picked off a Carson Palmer pass on the next Arizona drive which turned into more points by way of a 52-yard field goal from Steven Hauschka.The Cardinals would get their bearings on the next possession, marching 80 yards on 12 plays in 6:09. Palmer would hit Larry Fitzgerald on a 17-yard touchdown pass, but Chandler Catanzaro missed the extra point to make it a 10-6 game.That was pretty much the only Cardinal highlight in what was probably the most lifeless performance since the tail end of the Ken Whisenhunt era.Arians sensed something wasn’t up to snuff in the week of practice leading up to the game.“You lose games on Wednesday, Thursday and Friday. You don’t lose them on Sunday, in my opinion,” he said. “We lost this all week in practice.”The Cardinals managed only 232 yards of offense — their lowest total of the season. It’s also the first time they’ve been held to under 10 points in a game since last season. Arizona managed a total of three field goals in two games against Seattle in 2014, but those games were started by quarterbacks Drew Stanton and Ryan Lindley. Even with Palmer, a legitimate MVP candidate, things weren’t much different on Sunday. Derrick Hall satisfied with D-backs’ buying and selling Top Stories If you’re rooting for the Cardinals to finally break through and win a Super Bowl, you’re probably hoping the players in red and white disregarded that memo.The Seahawks dominated in every phase of the game from the outset, earning a 36-6 victory as their final push into the postseason.The Cardinals don’t possess that same momentum. After winning nine straight games, Arizona (13-3) is now wondering just what the heck went wrong Sunday.“This was a valuable lesson today, because you could see it coming all week,” Arians said. “I think coaches, players, everybody fell into that trap of reading their press clippings that anointed us Super Bowl champions. This was a nice wake-up call.”That wake-up call started early. Seattle (10-6) forced the Cardinals to punt on their first possession, then marched on a 12-play, 88-yard touchdown drive that melted 7:19 off the clock. Running back Bryce Brown punched it in from the 1-yard line to put the Seahawks on the board and set the tone for the entire contest.On the drive, Seattle kept the Cardinals’ defense off balance. Quarterback Russell Wilson went 5-for-5 for 45 yards — the biggest play being a 20-yard completion to tight end Cooper Helfet for 20 yards that gave the Seahawks a 1st-and-goal at the Arizona 1-yard line. Former Cardinals kicker Phil Dawson retires Seattle Seahawks running back Bryce Brown (36) scores a touchdown as Arizona Cardinals linebacker Sean Witherspoon (55) defends during the first half of an NFL football game, Sunday, Jan. 3, 2016, in Glendale, Ariz. (AP Photo/Rick Scuteri) Comments   Share   “Yeah, I’m pretty disappointed in myself and in us in the way we came out and played,” Palmer, who threw for 129 yards, said. “We got beat. We didn’t play well enough. Sometimes that’s a good thing going the way we had things going. It brings some guys back down to earth and get back to work.“It’s an opportunity to start another streak.”Fitzgerald likened the feel of this loss to the last time the Cardinals were faced with a less-than-important Week 17 matchup before a playoff appearance.“This had a similar feeling to the 33-7 loss to Green Bay (in 2009),” he said. “It’s Week 17 and we are heading to the playoffs, just from a mental standpoint I don’t think we were hitting on all cylinders. We have to get back tomorrow and address this film. Put the things that we did to rest and continue to build on what we have been doing the rest of the season.”In the season Fitzgerald referred to, the Cardinals bounced back from that season-ending loss to the Packers by handing them a 51-45 overtime loss in the Wild Card round the next week.Palmer agrees with his head coach and feels that this could be used as a valuable tool moving forward. GLENDALE, Ariz. — Last week, Cardinals head coach Bruce Arians was adamant that his team would treat Sunday’s regular-season finale against the Seattle Seahawks just like any other game.That sparked some debate locally. While Arians’ edict that his team will go out and play to win every week, regardless of the circumstances, held weight, some fans were concerned that such a philosophy would put important players at risk for injury. – / 39 “We were just a little too tentative, but it’s a great lesson to learn,” he said. “We have a lot of young guys and vets, like myself, that need to step up and make sure that doesn’t happen in the years ahead of us if we’re in that situation again.“That game is over. The regular season is over. Now the fun begins. We’ll be ready to rock.”Cornerback Patrick Peterson also chose to find a silver lining in a decisive loss.“A loss can help in a number of ways. We just want to make sure we that we don’t take that same approach in the playoffs,” he said. “We have to make sure that we have championship practices each and every day. We know how to get that job done, we know how to practice, just this week wasn’t our best.“At the end of the day, we will be back here in front of our crowd in two weeks and we will see what happens then. For the most part, we are still a good football team, we just have to go back to the drawing board and not let those little things to continue to creep up on us.”With the loss (and Carolina’s win over Tampa Bay), the Cardinals are the two-seed in the NFC in the playoffs. According to Arians, they’ll practice three times next week, during the bye, and like the rest of us, watch the Wild Card games and see whom they’ll host at University of Phoenix Stadium in two weeks. Grace expects Greinke trade to have emotional impactlast_img read more

Slovenian service provider T2 has tapped UKbased

first_imgSlovenian service provider T-2 has tapped UK-based outfit Amino to provide technology to support the operator’s launch of the country’s first 4K UHD TV service.Amino said it is deploying technology that will underpin a major service upgrade, which will expand T-2’s service to include 4K UHD content and value-added Video on Demand and Subscription VOD services.The company’s Enable software will power UHD content delivery and support a range of new features, including timeshift TV and advanced search for both in-home and mobile TV services.Ljubljana-based T-2 is Slovenia’s second largest IPTV operator by share and delivers a range of broadband, entertainment and voice over IP services across its own fibre-optic network, alongside mobile voice and broadband.T-2 chief strategy officer Gregor Štampohar said: “We want to provide our customers with the very latest entertainment experiences and Amino’s solutions have been a key factor in the successful launch of our new service offering. At the same time, we are also seeing the value of customer self-install of devices with considerable cost savings in terms of reduced engineering visits. It is our goal to offer our customers the best user experience.”Amino CEO Donald McGarva said: “Operators are now balancing the delivery of the latest high- quality consumer experiences around the home with a cost-effective drive to reduce installation and customer running costs. Our solutions are designed to meet these key objectives – and we’re delighted to be working closely with T-2 on their exciting rollout.”last_img read more

Could this be the Single Fastest Legal Way of Maki

first_imgCould this be the Single Fastest Legal Way of Making Money in America? Over the last 340 days, a secluded, California millionaire has been trading with a newly discovered system. Here are the complete results: For four years, I watched the companies of the S&P 500 as they traded around their earnings reports. I noted the volume, the consistency of the moves, the average percentage gain or loss, the option volume in the days before the announcement, the price of the options, the variation to historical premiums, and a whole host of other variables. Throughout that time, I logged all of that information onto 17 different spreadsheets. Each spreadsheet contains the data for each of the variables. That data helps to determine how important each variable is in predicting the stock’s movement after an earnings announcement. I then put all of those variables and percentages together and came up with an algorithm for an earnings trading system. I started trading the system with my own money in April 2016. By April 2017, the system generated 35 total trades. 32 of those trades were profitable. A $1,000 investment in each of those trades created profits of $17,547. So, a few months ago, I started sharing these trades with my Delta Report subscribers. We’ve executed seven trades so far. Six of them have been profitable – including an 80% gain in one day on Toll Brothers (TOL), a 100% gain in one day on Guess (GES), and another 80% one-day gain on our most recent trade in Oracle (ORCL). It’s that most recent trade in ORCL that has me quite excited about the potential for this upcoming earnings season. You see, on average, the system only generates about two or three earnings trades each month. Sometimes more, sometimes less, but on average about two or three. Last October, though, the system produced eight trades for me. That’s an active month. And it was hugely profitable, too. Seven of the eight trades were winners. I made 150% on Bristol-Myers Squibb (BMY), 186% on Intel (INTC), and a whopping 400% in one day on Sonic (SONC). The only loss last October was a 1.32% decline on some put options I bought on Lam Research (LRCX). If we get similar action this October, then I expect our earnings system trades will be quite profitable. And this season has already started off well… with a fast 80% gain on ORCL several days ago. That’s a good omen. Best regards and good trading, Recommended Link Jeff Clark Editor, Delta Report P.S. My trading experience goes back three decades. And the strategies I’ve used in that time were so successful, I was able to retire at age 42. These days, I spend most of my time at my California home. My neighbors think I’m growing marijuana… or flipping penny stocks. But what I’ve been working on is far more lucrative: this earnings algorithm. It’s brought my subscribers huge returns in short periods of time, like 100% in less than 24 hours. Click here to learn more. Reader Mailbag Another reader just finished Doug’s fantastic novel Speculator and is ready to start the next one in the series: Drug Lord. Both are must-reads here at the office… Hi, Doug, I rarely read fiction, but I wanted to read your latest book. I just finished your fabulous opus—Speculator. I wasn’t disappointed. Quite a read! Not only for the adventure, but also the political/social insights. And I always like a new idea: ideas as infections. That is a very good one. I look forward to reading Drug Lord. —David — Recommended Link — 3 Marijuana Stocks to Buy Right Now Canada is set to vote on a new nationwide law that will set off the biggest event in the history of marijuana. The Canadian pot market will explode from $400 million to $8 billion. And new marijuana millionaires will be minted. If you missed out on the first marijuana boom, when penny pot stocks delivered peak gains of 7,820%… 6,233%… and 3,986%… often in months… This is your second and final chance. Don’t miss out again. Discover the 3 companies that will dominate the marijuana market. Justin’s note: Today I’m handing over the reins to our good friend, master options trader Jeff Clark.In his essay below, Jeff shares details on one of his most successful trading strategies. With earnings season right around the corner, you don’t want to miss out on this… By Jeff Clark, editor, Delta Report Trading a stock around its earnings report is like gambling. It’s exciting. It’s fast action. And if you get the direction right, you can make a lot of money. But if you get it wrong, then you can kiss your hard-earned bucks goodbye. For the first 20 years of my career trading options, I loved to trade around earnings announcements. It was fast. It was exciting. But when I finally took an honest look at the results of my earnings trades, I found it wasn’t very profitable. Oh, sure, I had some big winners – trades that made me 300% or more on my money in just a few days. But I had plenty of trades where I lost 100% overnight, too. 10% in 24 hours (gain) 188% in 24 hours (gain) 3.5% in 6 days (gain) 3.1% in 24 hours (loss) 99.1% in 24 hours (gain) 10.53% in 6 days (gain) 6.27% in 4 days (gain) 4.44% in 6 days (gain)400% in 24 hours (gain) 150% in 24 hours (gain) 6.83% in 6 days (loss) 4.49% in 24 hours (gain) 6.25% in 24 hours (gain) 3.91% in 24 hours (gain) 13.19% in 24 hours (gain) 15.29% in 24 hours (gain)15.71% in 24 hours (gain) 9.18% in 24 hours (gain) 18% in 24 hours (loss) 9.24% in 24 hours (gain) 14% in 24 hours (gain) 185% in 24 hours (gain) Click here to discover more… After adding all of these trades together – more than 200 trades over 20 years – it turned out I was barely breaking even. It certainly wasn’t worth the time and effort it took to research all the ideas and put all the trading strategies together. So, I swore off earnings trades. As much as I enjoyed the action, I couldn’t justify putting in the effort for results that barely broke even. But in the back of my head, I always thought, “There must be some way to make this work.” For almost 10 years, I mostly watched the earnings action from the sidelines. Companies would report their numbers. The stocks would make a big move, either higher or lower. And I’d wonder if I would have gotten the direction right if I traded it. It was painful to stay on the sidelines, thinking about how much money I could have made if I had been on the right side of those moves. But in the few times during that period that I did dip my toe back into the earnings trading pool, the results were mixed, just like before. About five years ago, though, I decided to make a concentrated effort to determine if there was a way to get the direction right. Was the market sending clues that I wasn’t seeing? Could I put together a formula, an algorithm that would tell me – ahead of time – the most probable direction for a stock after its earnings announcement?last_img read more

When Joshua Mezrich was a medical student on the f

first_imgWhen Joshua Mezrich was a medical student on the first day of surgical rotation, he was called into the operating room to witness a kidney transplant.What he saw that day changed him.After the donor kidney came out of ice and the clamps on it were released, he says, “it turned pink and literally, in front of my eyes, this urine just started squirting out onto the field.”Mezrich was blown away: “I just had this sense like, ‘This is so amazing, what we’re doing, and what an incredible gift. And could I ever do this? Could I ever be part of this exchange, this beautiful thing?’ “He went on to become a transplant surgeon and has since performed hundreds of kidney, liver and pancreas transplants. He also has assisted in operations involving other organs.Each organ responds to transplant in a different way.”The liver will start pouring bile. The lungs start essentially breathing,” Mezrich says. “Maybe the most dramatic organ, of course, is the heart, because you put it in and you kind of hit it like you hit a computer, maybe you give a little shock and it just starts beating, and that’s pretty darn dramatic.”Mezrich is an associate professor in the division of multiorgan transplantation at the University of Wisconsin School of Medicine and Public Health in Madison. He reflects on his experiences as a transplant surgeon and shares stories from the operating room in his book, When Death Becomes Life.Interview HighlightsOn the different types of organ donors There are a few different scenarios [where] we take organs from deceased donors, the most common being those that are brain-dead. Those patients have no blood flow to their brain, so they’re considered legally dead, but their heart is still beating, their organs are getting blood flow, and they’re often in a fairly stable situation, so we can take our time.There’s a second type of donor, which we call “DCD,” or donation after circulatory death. These patients are actually still officially alive, but they’ve reached the point where the decision has been made to withdraw support. And in those patients, we wait to withdraw support until everything has been discussed, and often the family is in the room when that support is withdrawn by their primary doctor, not by us. …You know, it’s an interesting thing, because you really think about what really is death? How is it defined? Do patients feel the same way as we do? These are kind of some of the really interesting challenging parts of being in this field.On how transplant takes a long time and requires stamina from doctorsI train a lot of people in transplantation, we call them fellows. … These are people who’ve finished their general surgery residency and now they’re getting additional training [in] transplant, and they’re excellent. … Being a surgeon, particularly liver transplant, is all about kind of intestinal fortitude or inner strength. You’ve just gotta keep your wits and stay strong through all the different things that maybe can go wrong and fight through it. That’s certainly what a liver transplant is like.On having to make the judgment call about giving livers to patients with alcoholic liver disease Transplant is one of those things that it’s an amazing science and the surgery is very heroic, but if there isn’t the social support and the ability to take care of the organ, it’ll surely fail. You have to take all these medications to prevent rejection. You have to follow up a lot. Sometimes you have to battle through different complications, and so it really requires a village, if you will, to support any type of transplant.This is a really important topic when we think about liver transplantation. So in the early days of liver transplant — ’60s, ’70s — initially people decided not to transplant patients with alcoholic liver disease because of the thought that they did this to themselves and maybe they didn’t deserve it. I think now most people would agree that alcoholism is a disease, and it’s a disease that is hard to treat and it can come back.So rather than maybe think about it as, “These people are being stupid,” or they’re like your silly friends who drink too much, they truly have this addiction and it’s a disease like other diseases, like hepatitis C, like the other things we transplant with more complex names. And it’s been shown that we can get good outcomes in patients with alcoholic liver disease, as long as they have insight into their disease, and kind of have a support system to try and deal with the transplant afterwards.But it is controversial, because patients with alcoholic liver disease often have a lot of failed relationships, have a lot of challenges in their life, don’t have great family support. It’s challenging to talk about some of these patients and wonder if we are going to get the best outcome, if this transplant is actually going to fix their problem or not. I think our health care system likes these heroic treatments like a liver transplant, but we don’t put enough into prevention, into really understanding and managing the disease, and that can be sometimes a challenge. We’ve had many incredible victories with transplanting livers into [patients with] alcoholic liver disease but we’ve also had some dramatic failures.On what it’s like talking to the families of donors This is really one of, in my opinion, the most special parts of being in my field of being a transplant surgeon. I was really nervous the first time I met a donor family because I thought they were gonna look at me and think I’m this vulture who is taking the organs out of their loved one, and I could only imagine the images they might have had.But I’ll never forget that interaction and most that I’ve had with the donors: They hung on every word. … They wanted to know about the recipients. It truly was this beautiful legacy of their loved one, often who has died unexpectedly, sometimes a young person, and it gives them this positive thing to hold onto in this otherwise terrible time.It is so incredibly special, and I truly believe the donors, even the deceased donors, are our patients just as much as the recipients. It’s so important that we connect with the family, that we let them understand the process, that we are able to do a great job to make this incredible gift work. It’s quite emotional. It really is an incredible bond when we interact with these families.On saying a few words about the donor before the operation begins I want to reiterate as many times as possible how important the donors are, how much they’re heroes to us, and we always want to remember their stories and this gift that they’re giving. It’s very emotional when we go on these procurements, and in our group when we go on a procurement, when we’re in the operating room, we always take a pause and our people from our organ procurement team will, after a moment of silence, will read something. Often it’s a poem or something that one of the loved ones asked us to say about the person, maybe a little bit about who they were, what was important to them. Sometimes it has a religious base, sometimes it doesn’t.And we all kind of sit and think about it, and it is very special. It’s emotional. And then the second that’s over, we move on and really go after the task at hand. So it’s interesting. You have this emotional experience, and then you have to very quickly kind of push it out of the way and and move on to the operation, but it’s always very special.Sam Briger and Mooj Zadie produced and edited the audio of this interview. Bridget Bentz, Molly Seavy-Nesper and Scott Hensley adapted it for the Web. Copyright 2019 Fresh Air. To see more, visit Fresh Air.last_img read more

Google Is No Longer Working on HighAltitude Drones

first_img This story originally appeared on PCMag Image credit: Google via PC Mag The program ended in early 2016 to focus on Internet delivery via balloons instead. Google –shares Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. January 12, 2017 News reporter Enroll Now for $5center_img Google Is No Longer Working on High-Altitude Drones 2 min read Fireside Chat | July 25: Three Surprising Ways to Build Your Brand Add to Queue Google has suspended research on its solar-powered drone, the company confirmed on Wednesday, less than three years after inheriting the project through its acquisition of Titan Aerospace.First reported by 9to5Google on Wednesday, the drone cancellation took place early in 2016, according to a representative from the X subsidiary of Google’s parent company, Alphabet. The representative told PCMag that X plans to refocus its efforts on development of a high-altitude balloon called Loon that can deliver internet access to remote areas, as well as the Project Wing drone delivery service.  “The team from Titan was brought into X in late 2015,” X Communications Manager Jacquelyn Miller wrote in an email to PCMag. “We ended our exploration of high altitude UAVs for internet access shortly after.”Miller explained that the decision to stop drone research was one of several reorganizations that occurred after Alphabet was established, but that X’s overall mission to expiriment with alternative ways of delivering Internet access hadn’t changed.”By comparison, at this stage the economics and technical feasibility of Project Loon present a much more promising way to connect rural and remote parts of the world,” she wrote. “Many people from the Titan team are now using their expertise as part of other high flying projects at X, including Loon and Project Wing.”The challenges of delivering Internet access via solar-powered drones have not deterred Facebook, which performed a test flight of its own Aquila drone last year. That flight ended in disaster, however, when the prototype crashed due to a structural failure.Facebook was also rumored to be interested in Titan Aerospace before Google acquired it in 2014. The company instead picked up UK-based Ascenta, which had also been working on solar-powered drones. Tom Brant Next Article last_img read more

Ready to Ride Hyperloop One Completes Testing Tube

first_imgHyperloop April 7, 2017 Learn how to successfully navigate family business dynamics and build businesses that excel. Next Article News reporter Register Now » Add to Queue Ready to Ride? Hyperloop One Completes Testing Tube. Free Webinar | July 31: Secrets to Running a Successful Family Businesscenter_img Image credit: Hyperloop One via PC Mag This story originally appeared on PCMag Since its first demonstration last year of the hyperloop technology that could one day propel travelers in underground pods at jet-like speeds, the startup Hyperloop One has upgraded its test track in the Nevada desert to make its case for what it hopes will be the future of intercity transportation worldwide.Hyperloop One put the finishing touches on its 1,640-foot testing tube in North Las Vegas this week. Inside the tube, pods filled with passengers and cargo will magnetically levitate and accelerate via electric propulsion to speeds approaching those of a commercial airliner. Such high speeds are attainable because of the tube’s low atmospheric pressure, which contributes to reduced aerodynamic drag. The company plans to have a team of 500 engineers, fabricators, scientists and other employees working on its technology by the end of the year. That’s a big increase from last year, when the company had fewer than 100 engineers, many of them ex-NASA Jet Propulsion Laboratory employees based at the company’s headquarters in California.Last May, those engineers demonstrated their propulsion technology in front of hundreds of journalists. A small white sled accelerated to more than 100 miles an hour over a straight track of a few hundred meters, and the entire test lasted less than five seconds. One of the ex-JPL engineers, Cassandra Mercury, said at the time that the company was looking forward to testing the completed design.”We’re going to have it levitating, in a tube, with a pod, at vacuum,” she told PCMag. “That’s why they’re calling it the Kitty Hawk moment.” With the tube now completed, those tests can begin, although the company did not offer a timeframe.In addition to overcoming technological hurdles, the company has also faced legal ones: co-founder and CTO Brogan BamBrogan, along with other former employees, sued the company last summer for wrongful termination, alleging, among other things, that they were forced out for speaking to investors about cultural issues within the futuristic firm.Hyperloop One CEO Rob Lloyd said in a statement on Wednesday that the technology will “transform transportation as we know it.” He is currently promoting the hyperloop as a feasible alternative to driving or flying between cities in the same region, such as Los Angeles to San Diego, Miami to Orlando and Seattle to Portland. –shares Tom Brant 2 min read The hyperloop could take travelers and cargo between nearby cities in underground pods traveling at jet-like speeds.last_img read more

Hilton Uncovers Malware in Payments Systems

first_imgData Breach Hilton Uncovers Malware in Payments Systems Learn how to successfully navigate family business dynamics and build businesses that excel. November 25, 2015 Reuters Hotel chain operator Hilton Worldwide Holdings Inc said on Tuesday it identified unauthorized malware in some payment systems that targeted payment card information.A third-party investigation found that the malware targeted specific payment card information, that included cardholder names, payment card numbers, security codes and expiration dates, Hilton said.The information targeted, however, did not include addresses or personal identification numbers (PINs), the company added.Hilton said customers who used their cards during a 17-week period – from Nov. 18 to Dec. 5, 2014 or April 21 to July 27, 2015 – were advised to check their bank statements.The owner of the Conrad and Double Tree hotel chains did not provide details on the number of cards affected.The news comes less than a week after rival Starwood Hotels & Resorts Worldwide Inc said that 54 of its hotels in North America had been infected with a malware designed to collect payment card data.Shares of the company were unchanged in extended trading on Tuesday. They closed at $23.45 on the New York Stock Exchange.(Reporting by Sruthi Shankar in Bengaluru; Editing by Siddharth Cavale) –shares Free Webinar | July 31: Secrets to Running a Successful Family Business Next Article Add to Queue 1 min read This story originally appeared on Reuters Register Now »last_img read more

Study shows outcomes of CAR Tcell therapy when used as standard of

first_imgReviewed by Kate Anderton, B.Sc. (Editor)Dec 3 2018Chimeric antigen receptor T-cell therapy, or CAR T, was named the 2017 Advance of the Year by the American Society of Clinical Oncology. The FDA approved two CAR T products last year for treatment of adult large B-cell lymphoma based on the exceptional patient outcomes seen in clinical trials. Now, a follow-up study of one of those products shows that it matches clinical trial outcomes when used as a standard of care.Moffitt Cancer Center partnered with 16 academic cancer centers to analyze real world data of 274 patients treated commercially with Yescarta® (axicabtagene ciloleucel), one of two CAR T products that is now standard of care for patients with diffuse large B cell lymphoma (DLBCL) who have not responded to two or more therapies. The researchers then compared those figures with results from the pivotal ZUMA-1 trial, which included 101 patients. The final comparison results, which were presented Saturday, Dec. 1 at the American Society of Hematology Annual Meeting, showed Yescarta induces remissions in DLBCL patients when administered as a standard of care.Related StoriesNanoparticles used to deliver CRISPR gene editing tools into the cellNew study reveals ‘clutch’ proteins responsible for putting T cell activation ‘into gear’Mathematical model helps quantify metastatic cell behavior”Now that Yescarta is a standard of care for patients with large B cell lymphoma that has progressed after two prior lines of therapy, we wanted to compare the standard of care outcomes, including response rates and onset of side effects, with the results from the clinical trial that led to the therapy’s approval,” said Michael Jain, M.D., Ph.D., co-first author of the study and assistant member of Moffitt’s Blood and Marrow Transplant and Cellular Immunotherapy. “Our results showed that patient response rates, and the toxicity profile, were consistent with the ZUMA-1 trial results.”The real world data showed that at a median follow-up of four months, 81 percent of patients in the standard of care group responded to the therapy with 58 percent showing no detectable cancer. At the time of Yescarta’s FDA approval (Oct. 2017), results from the ZUMA-1 clinical trial showed 72 percent of patients treated responded to therapy including 51 percent who had no detectable cancer remaining at a median follow-up of 7.9 months.”This study echoes the early results in the ZUMA-1 clinical trial and provides further evidences that CAR T-cell therapy, such as Yescarta, is a feasible option for patients who would otherwise have no viable treatments options,” said Frederick Locke, M.D., associate member and vice chair of the Blood and Marrow Transplant and Cellular Immunotherapy Department, and co-leader of the Immunology Program at Moffitt., who served as co-senior author of the study.Source: https://moffitt.org/newsroom/press-release-archive/2018/new-study-highlights-car-t-cell-therapy-success-for-lymphoma-when-used-as-standard-of-care/last_img read more

Toyota SoftBank setting up mobility services joint venture

first_img SoftBank Group Corp. Chairman Masayoshi Son, left, and Toyota Chief Executive Akio Toyoda attend during a joint press conference in Tokyo Thursday, Oct. 4, 2018. Japan’s No. 1 automaker Toyota Motor Corp. and technology giant SoftBank Group Corp. are setting up a joint venture to create mobility services in what they called a “united Japan” effort to face global competition. (AP Photo/Eugene Hoshiko) Citation: Toyota, SoftBank setting up mobility services joint venture (2018, October 4) retrieved 17 July 2019 from https://phys.org/news/2018-10-toyota-softbank-mobility-joint-venture.html The 2 billion yen ($20 million) venture, Monet Technologies Corp. is meant to be running by the end of March.It will work on on-demand vehicle services, food deliveries, data analysis and hospital shuttles with onboard medical exams, the companies said Thursday in a news conference at a Tokyo hotel.”Many of you here may be asking why Toyota and SoftBank?” Toyota Chief Executive Akio Toyoda said of the odd-couple union of an old-style manufacturer with a relative newcomer like SoftBank.The energy and telecoms company’s past tie-ups have tended to be with overseas startups. But Softbank has also invested in leading car-sharing companies like Uber, Didi and Grab, and has acquired Arm, a leader in the Internet of Things, or IoT.Toyoda stressed the auto industry was changing in an era of connected cars, autonomous driving, car-sharing and electric vehicles.”We want to change,” said Toyoda.SoftBank Chairman Masayoshi Son said he was thrilled to be partnering with a top automaker on mobility and artificial intelligence, his company’s expertise. Honda, GM to develop electric vehicle batteries together This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2018 The Associated Press. All rights reserved. Earlier this week, Toyota’s Japanese rival Honda Motor Co. said it was investing $2.75 billion in GM Cruise, an autonomous-vehicle unit run by General Motors Co. of the U.S.Softbank is also an investor in GM Cruise. Uber has announced a partnership with Toyota.Other autonomous-drive partnerships include BMW with Fiat Chrysler, chipmaker Intel and visual recognition software maker Mobileye; and German automaker Daimler AG with supplier Bosch to develop autonomous taxis.Google’s Waymo in the U.S. plans to put autonomous vehicles on the road in a ride-sharing service in the Phoenix area before the end of this year. U.S. electric-car maker Tesla is also developing autonomous vehicles.”This may look like an unusual combination,” said SoftBank’s executive in charge of technology, Junichi Miyakawa. “But Japan must compete with the rest of the world. That is why we are shaking hands today.” Junichi Miyakawa, left, Representative Director and CTO of SoftBank Corp. and Shigeki Tomoyama, right, Executive Vice President of Toyota Motor Corporation attend during a joint press conference in Tokyo Thursday, Oct. 4, 2018. Japan’s No. 1 automaker Toyota Motor Corp. and technology giant SoftBank Group Corp. say they are setting up a joint venture to create mobility services. (AP Photo/Eugene Hoshiko) Representative Director and CTO of SoftBank Corp. Junichi Miyakawa, left and Executive Vice President of Toyota Motor Corporation Shigeki Tomoyama, right, shake hands during a press conference in Tokyo Thursday, Oct. 4, 2018. Japan’s No. 1 automaker Toyota Motor Corp. and Japanese technology giant SoftBank Group Corp. say they are setting up a joint venture to create mobility services. (AP Photo/Eugene Hoshiko) Softbank Group Corp. Chairman Masayoshi Son, left, and Akio Toyoda, right, President of Toyota Motor Corporation shank hands during a press conference in Tokyo Thursday, Oct. 4, 2018. Japan’s No. 1 automaker Toyota Motor Corp. and technology giant SoftBank Group Corp. say they are setting up a joint venture to create mobility services. (AP Photo/Eugene Hoshiko) SoftBank Group Corp. Chairman Masayoshi Son, left, and Toyota Chief Executive Akio Toyoda attend during a joint press conference in Tokyo Thursday, Oct. 4, 2018. Japan’s No. 1 automaker Toyota Motor Corp. and technology giant SoftBank Group Corp. are setting up a joint venture to create mobility services in what they called a “united Japan” effort to face global competition. (AP Photo/Eugene Hoshiko) Junichi Miyakawa, left, Representative Director and CTO of SoftBank Corp. speaks during a joint press conference with Toyota Motor Corporation in Tokyo Thursday, Oct. 4, 2018. Japan’s No. 1 automaker Toyota Motor Corp. and technology giant SoftBank Group Corp. say they are setting up a joint venture to create mobility services. (AP Photo/Eugene Hoshiko) Explore further Softbank Group Corp. Chairman Masayoshi Son, left, and Akio Toyoda, right, President of Toyota Motor Corporation shank hands during a press conference in Tokyo Thursday, Oct. 4, 2018. Japan’s No. 1 automaker Toyota Motor Corp. and technology giant SoftBank Group Corp. say they are setting up a joint venture to create mobility services. (AP Photo/Eugene Hoshiko) Japan’s No. 1 automaker Toyota Motor and technology giant SoftBank Group are setting up a joint venture to create mobility services in what they called a “united Japan” effort to face global competition. Softbank Group Corp. Chairman Masayoshi Son, left, and Akio Toyoda, right, President of Toyota Motor Corporation bow during a photo session of a joint press conference in Tokyo Thursday, Oct. 4, 2018. Japan’s No. 1 automaker Toyota Motor Corp. and technology giant SoftBank Group Corp. say they are setting up a joint venture to create mobility services. (AP Photo/Eugene Hoshiko) “I’m so excited just thinking about it,” he said, appearing with Toyoda. The two executives praised each other profusely after the news conference.The joint venture’s services will roll out in Japan first, but a global expansion is in the works, the companies said. It’s 50.25 percent owned by SoftBank, 49.75 percent by Toyota.Toyota is developing autonomous vehicles in time for the 2020 Tokyo Olympics and Monet plans to roll out a business featuring autonomous vehicle services by the second half of 2020, they said.Automakers around the world are forming tie-ups in the race to develop the next-generation of transportation, such as self-driving cars.last_img read more

Game on Fiverr offers coaches for Fortnite PUBG players

first_imgFortnite and PUBG have been worldwide runaway successes. Both games have an arena-style survival concept, called “battle royale”, where 100 gamers are dropped onto an island to fight each other for survival. — Reuters Fiverr International Ltd is tapping into the phenomenal success of Fortnite and PUBG by hooking up players with online gaming experts, who will help them up their game while helping the company make some money in the process.Fiverr on July 11 unveiled an online store focused on the booming interest in video and mobile games that will let game experts sell their special skill sets to prospective players.Fortnite and PUBG have been worldwide runaway successes. Both games have an arena-style survival concept, called “battle royale”, where 100 gamers are dropped onto an island to fight each other for survival.From as little as US$5 (RM21), players can enrol on the site to learn survival skills and how to choose the best landing spots and guns. Tech News 28 Jun 2019 PUBG developing a story-based game Related News Tags / Keywords: Fortnite , PUBG Tech News 10 Jul 2019 PC download charts: ‘PUBG’, ‘Monster Hunter World’, ‘GTA V’ head sale week ranking Founded in 2010, Fiverr makes money from commissions by connecting people with professionals offering various services on its freelance services platform.Along with game coaching, buyers and sellers can trade “gigs”, or services in 30 categories ranging from developing a game to polishing game streaming on platforms such as Twitch.The gaming industry, which has seen massive growth in the past few years, is now dominated by last-man-standing multiplayer games that generate hundreds of millions in revenue by selling character outfits and add-ons.Fortnite was launched in 2017 and its popularity has pushed the valuation of its publisher Epic Games to US$15bil (RM61.68bil) in a funding round last year. Gamers have also flocked to Electronic Arts Inc’s Apex Legends and Tencent Holdings Ltd’s PlayerUnknown’s Battlegrounds (PUBG).The numbers of gamers is expected to rise more with the launch of Apple Inc’s subscription-based game service Apple Arcade this fall and Alphabet Inc’s browser-based videogame streaming service Google Stadia.”We want to help power the current growth that exists in the broader gaming industry, with the freelance talent and services to help game creators meet their needs,” Fiverr chief executive officer Micha Kaufman said. – Reuters {{category}} {{time}} {{title}} Related News Tech News 18 Apr 2019 Iraq parliament bans online battle games, citing ‘negative’ influencelast_img read more